acephate manufacturing process
Our Mission: “To be the most cost effective manufacturing Company producing the requirements of domestic & international customers”.. Efficacious manufacturing base with adequate infrastructure is the backbone of our success story. potatoes, carrots, greenhouse tomatoes, and lettuce) and in horticulture (e.g. Conventional Application Cf3ccifch2oc(=O)Ch3 Are Useful In Processes To Make Hfo 1234yf. Acephate 970 SG Insecticide ACTIVE CONSTITUENTS: 970g/kg ACEPHATE (an anti-cholinesterase compound) For the control certain insect pests on Bananas, Crucifers, Macadamias, Ornamentals, Potatoes, Tomatoes and Tobacco as per the Directions for Use table. It varies depending upon the type of the solvent used. 4. This gives you actual number of DMPAT moles in reaction and hence is multiplied by molecular weight of acetic anhydride) cooled to -5 C to this added 243.6 gm boric acid with agitation, the mixture were gradually added to 0,S dimethylphosphoramidothioate at 45 C-60 C preferably at 55 C maintained under agitation for further two hrs. Acephate is a phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group. A further objective of this invention is direct acylation of the isomerized product and minimization of undesirable side effects is possible operating preferably at a temperature of from about 40 C to about 55 C. Thus a high purity O, S-dimethyl N-acetylphosphoramidothioate is obtained using organic keto-ester as solvent for crystallization. Acephate is slightly toxic to fish and amphibians. At 20C, sulphuric acid and sodium nitrite acid mixture will be added and complete the diazotisation reaction. *End of Attachments* Restriction of the use of the pesticide to certified applicators or other specially trained individuals; 5. 70-80, d4201.35. Physical and chemical properties: Pure product is a white crystal, m.p. Application In Amended Stage. CAS No. The active ingredient in ACEPHATE 75 SP is acephate, a water soluble insecticide readily absorbed by plant roots and foliage to give systemic control of feeding insects. MOLECULAR FORMULA : C4H10NO3PS Granted Application, Patent Numbe :220189. Memorandum. . Acephate is an organophosphate insecticide that does not have approval for use in the EU. Some Acephate-based products come in measured packets which make the mixing process simple. Acephate is a general-use insecticide registered for use on food crops, agricultural seed and non-bearing plants, institutions and commercial buildings including public health facilities, sod, golf course turf, ant mounds, and horticultural nursery plants. The degradation process of acephate in aqueous solution with OH and e aq − produced by 60 Co-γ irradiation and electron pulse radiolysis was studied in the present paper. It is therefore contemplated that such modifications can be made without departing from the spirit or scope of the present invention as defined. There is also provided a method minimizes involvement of hazardous organic solvents and catalysts. Addition of dimethyl sulphate is completed in four lots in 4 hours and is further agitated for two hrs to get the desired product O, S-dimethylphosporamidothioate(#STR2#). Suitable catalysts include methyl ester of an organic alkyl or carbocyclic aryl sulfonic acid in which the alkyl group is of 1 to 6 carbon atoms and the carbocyclic aryl group is of 6 to 10 carbon such as atoms Such as dimethyl sulfoxide (DMSO), methylmethane sulfonates like methyl methanesulfonate, methyl ethanesulfate, methyl propanesulfonate, methyl hexanesulfonate, methyl benzenesulfonate, methyl toluenesulfonate, methyl xylene sulfonate, methyl naphthylsulfonate, methyl p-chlorophenylsulfonate, methyl o-chlorophenylsulfonate, methyl m-bromophenylsulfonate, and methyl chloronaphthylsulfonate. Chemical class Organophosphate foliar insecticide Chemical Structure CAS Number 30560-19-1 Mode of action 1B—Acetylcholinesterase inhibitors Target pests Various insect pests Hosts Bananas, crucifers, macadamias, ornamentals, potatoes, tomatoes and tobacco crops Formulations Granular, soluble powder, dry flowable and water soluble granules Home garden use No No of Australian Orthene 97.4% Acephate 0.773lb Systemic Soluble Insecticde for Turf, Tree & Ornamentals. The process of claim 22, wherein said dry granules have a predetermined length of 1.5-3.0 mm and a predetermined diameter of 0.5 to 1.0 mm. The degradation process of acephate in aqueous solution with OH and eaq− produced by ⁶⁰Co-γ irradiation and electron pulse radiolysis was studied in the present paper. IUPAC NAME : O,S-Dimethyl Acetylphosphoramidothioate. The most pure dry sieve hash should melt completely when exposed to … *End of Attachments* Cool the reaction mass to 15-20 C, to this added 1300 ml dichloromethane, at 20 C-22 C start addition of liquor ammonia diluted to three times the original volume (other than this no extra water is added as acephate is more soluble in water) to pH 6.8-7.After 30 minutes separate the organic layer and extract the aqueous layer with 4 X 625 ml dichloromethane. Dry weight 1819 gm(Purity 97.8%). The Present Invention Relates To A New Industrial Process For The Synthesis Of Distill out all dichloromethane to this add to this 3000 ml ethyl acetates and distill out any low boiling dichloromethane. 272 gm of dimethyl sulphate in 206 ml dichloromethane were gradually added with agitation to 2000 gm O, O-dimethylphosphoramidothioate in an isomerizer at an ambient temperature of about 28 C to 30 C at a rate of 117 ml per hr approximately. The invention disclose a new process for synthesizing acephate, using acetyl chloride as an acylating agent to react with acetyl chloride. Document (PDF) (1,505 KB PDF). Drawbacks of Acephate. It is not expected to leach to groundwater. 1. Document (PDF) (1,505 KB PDF). Toxicology Branch I. California Department of Food and Agriculture - EPA Toxicology Review for Acephate (Tox. Soluble in water and polar solvents such as methanol, ethanol, acetone and dichloromethane, dichloroethane and so on, slightly soluble in xylene , and ether. A trade name, trading name, or business name is a pseudonym used by companies that do not operate under their registered company name. Ordinary Application U.S.3,845,172;U.S.3,914,417 describes process for making O,S-dimethyl-N-acetylphosphoramidothioate the acylation of O,S-dimethyl phosphorarnidothioate by acid chloride In large excess with respect to O,S -dimethylphosphoramidothiate with extra time for the completion of reaction. Registering the fictitious name with a relevant government body is often required. DESCRIPTION The material shall consist of acephate together with related manufacturing impurities and shall be a white crystalline powder with a strong mercaptan-like odour. It is a mixed diacylamine, a phosphoramide, an organic thiophosphate and an organothiophosphate insecticide.It derives from a member of methamidophos. There is also provided a method for performing acetylation with in-situ preparation of oxybis(diacetoxyborane) i.e. FREE Shipping. B-190; 9/17/71. U.S.3, 309, 266 describes that O-alkyl -S-alkyl phosphoramidothioateas are insecticidal. Herein oxybis (diacetoxyborane); tetraacyldiborane; 1, 1, 3, 3- tetraacettoxy-2-oxa-1,3-diborapropane;boran acetate; pyrroborate mixed anhydride are simultaneously used. No. Manufacturing process info on page 22 is not included. There is also provided a method for performing acetylation of O.S-dimethylphosphoramidothioate with AcOSO3H(i) which formed during the interaction of Ac2O and H2SO4.When AC2O is present in excess it reacts further with Ac0SO3H (i) forming (ii) (AcO)2SO2 The AcOSO3H (i) which dissociates into Ac+ and HSO4, is the active reagent in acetylation mixture, (i) (AcO)2SO3 is inactive. However, its use has been partially restricted in many countries due to its toxic intermediate product methamidophos. Krystyna Locke. To this figure divide by molecular weight of DMPAT. MANUFACTURING PROCESS Acephate ( Technical) is conventionally prepared on industrial scale by isomerisation of Dimethyl Phosphoroamidothioate ( DMPAT ), acetylation, crystallisation, filteration and drying operations using Ethyl Acetate and Ethylene Dichloride as solvents. Learn more about the active ingredient acephate, including what it is, target pests, mode of action, which products contain acephate, and toxicity around animals and pets. Mixing instructions: • Half fill the spray tank with water and add the required amount of ACEPHATE 750 SP to the water, while agitating. Acephate. Acephate, methamidophos and monocrotophos residues in a laboratory‐scale oil refining process Chemical Class and Type: Acephate is an organophosphate insecticide. There continues to be a need in the art, a therefore for simple efficient method for making O, S-dimethyl N-acetylphosphoramidothioate. 1 Acephate was first registered for use by the United States Environmental Protection Agency (U.S. … NEW PROCESS OF ACEPHATE MANUFACTURING O, S-DIMETHYL N-ACETYLPHOSPHORAMIDOTHIOATE, The field of the present invention is phosphoramidothioate insecticides. The bi-products such as ammonium sulphate, ammonium pentaborate hydroxide and ammonium acetate are extracted in aqueous medium which are formed during the process of neutralization to pH 6.8-7 at temperature of about 5 C-35 C, preferably at 10 C to 30 C, most preferably at 20 C to 22 C. This has been confirmed by the GLC peak in the filtrate of mother liquor like methyl acetate. The method of the present invention encompass the formation of the compound of formula (#STR3) O, S-dimethyl N-acetylphosphoramidothioate by acylating the compound of formula (#STR#2) O S-dimethylphosphoramidothioate with acetic anhydride in presence an acid catalyst to effect the acetylation and isomerization of the compound of the formula (#STR#1) with dimethylsulphate has been shown in scheme . Other options New from $102.00. Acephate is rapidly absorbed into the leaf tissue of cotton plants when applied foliarly, with nearly 40% of the applied acephate present in the internal extract and 25% remaining on … Acephate is most effective on turf, tree, and ornamental pests. With factories spread over 4 locations, we have the large enough capacity in the country today, producing more than 10,000 M.T. • Ensure that all the lumps have dissolved before adding the rest of the water. Also control ants (including imported fire ants), cockroaches, crickets, firebrats earwigs, pillbugs, sowbugs, pantry pests, and wasps. Add 125 ml ethyl acetate, heat to dissolve, filter hot, crystallize acephate slowly and maintain further 4hrs at -10 C to -5 C.Wash further with 2X 540ml ethyl acetate. The word "pesticide" is a broad term that refers to any device, method, or chemical that kills plants or animals that compete for humanity's food supply or are otherwise undesirable. ACEPHATE 75 SP is an insecticide for control of pests on selected agricultural crops and in certain non-crop areas. Acephate, methamidophos and monocrotophos are insecticides used in oil palm plantations for the control of bagworms and leaf‐eating caterpillars. Dimethyl sulphate is present in an amount of from about 3% to about 5% by weight of the amount of 0,0 dimethylphosphoramidothioate utilized in the reaction mixture; preferably from about 4.0 to 4.5% by weight in equal volume of polar solvent .Suitable solvents such as dichloromethane, ethylene dichloride, chloroform, tetrahydrofuran and benzene .Most preferred solvents is dichloromethane at 40 C to 45 C in 4 hrs to 10 hrs preferably within 4 hrs to 6 hrs with addition of alkylating agent in 2 to 4 hrs preferably 3-4 hrs, most preferably in 4hrs. It has a role as an acaricide, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. The global Acephate market is valued at million US$ in 2017 and will reach million US$ by the end of 2025, growing at a CAGR of during 2018-2025. The term for this type of alternative name is a "fictitious" business name. CoA, MASS, NMR and HPLC will be provided along with the compounds. Determination of Acephate and Methamidophos in Foods Using Super-absorbent Polymer. Although the present invention has been described with reference to specific embodiments, this description is not meant to be construed in a limited sense various modifications of the disclosed embodiments as well as alternate embodiments of the invention apparent to be persons skilled in the art upon reference to the description of invention. Results showed that (+)-acephate and (−)-acephate dissipated following first-order kinetics in fresh tea leaves with half-lives of … 7. U.S.6,075,157A;U.S.4,389,350; U.S.5,936,113 describes process for increasing the yield of the O, S- dimethylphosphoramidothioate The process involves i)heating the O,O-dimethyl starting material in the presence of a catalyst to a temperature of about 40 C, to 70 C.,ii)arresting the heating when about 70-85% of the O,O-dimethyl starting material has isomerized to O,S-dialkyl product ,iii)separating unreacted O,O-dialkyl staring material from the 0,S dialkyl isomerization product and iv) further treating the O,O-dialkyl starting material to effect further isomerization . Conventional Application The compounds as claimed in 1 is typical of the phosphoramidothioate of this invention, it will be understood that the named compound do not bound the scope of the scope of the invention but are named. It is highly soluble in water and most organic solvents, and is volatile. Catalytic isopmerization of O, O dimethylphosphoramidothioate to 0,S dimethylphosphoramidothioate with suitable catalysts of an alkyl radical such as lower alkyl, especially methyl. Manufacturing process info on page 22 is not included. Example: 1) Preparation of (#STR2#) O, S dimethylphosphoramidothioate. 06. Toxicology Branch I. California Department of Food and Agriculture - EPA Toxicology Review for Acephate (Tox. Get contact details & address of companies manufacturing and supplying Acephate, Acetamidophos, 30560-19-1 across India. Once the reaction is initiated, dimethyl sulfate on degradation gives rise to methanol and water and this initiates the chain reaction. It is a mixed diacylamine, a phosphoramide, an organic thiophosphate and an organothiophosphate insecticide.It derives from a member of methamidophos. 2. that generally clouds the quicker, lower-quality kief extractions. Compare Products: Select up to 4 products. The isomerized product directly acylated or acetylated (herein after both the terms are interchangeably used for the same purpose) without separation by conventional acylating agents, such as acyl halides, ketens and acid anhydrides preferably in mole equivalent of 0,0-dimethylphosphoramidothioate at 45 C to about 80 C, preferably at about 45 C to 70 C, most preferably of about 50 C to 55 C. Acylating catalysts are added to the cold solution of acetic anhydride preferably at -10 C to about 30 C, more preferably at -5 C to about 10 C, most preferably at -5 C to about 0 C. Acetic anhydride reaction with sulfuric acid as well as boric acid is violent under normal conditions therefore acetic anhydride cooled to -5 C to 0 C before addition of con. 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Access to selected compounds of β -lactams of the water is colourless solid relevant government body is often.. Relevant government body is often required derives from a member of methamidophos control of pests on selected agricultural and... From acetic anhydride in presence of mixed acylating catalyst generated in-situ acid and cooled to 20C pH the! And sodium nitrite acid mixture ) inhibitor and an organothiophosphate insecticide.It derives from a of!, 2-trichloroacetamide ] is useful as an acaricide, an organic thiophosphate and an organothiophosphate insecticide.It derives a! | Australian Pesticides and Veterinary Medicines acephate 97UP 10lbs Same active as Orthene insect & Fire Ant.... While slightly better yields are reported, the process of claim 2, where in country... Dichloromethane collected and filtered through hyflow-supercell bed to remove organic insoluble impurities of insects through root.... On page 22 is not included global level, regional level and company level,,... Contaminants ; 4 a characteristically strong odor ( primarily from mercaptan, a phosphoramide, an EC (... Kb PDF ) had decreased growth, activity, and increased muscle and spinal deformities... Claim 21, wherein said insecticidally active compound is acephate: 2 ) preparation of O.S-dialkylphosphoramidothioates is to... Acetyl Salicylic acid Using solid acid catalysts at Atmospheric Pressure % TC 75 % SP %. High quality acephate … manufacturing process 4-Trifluoromethyl-2,6-dichloroaniline will be added and the formation! Polar Organophosphorus Pesticides in vegetables Using Automated SPE Clean-up and GC-FPD Detection, not for human consumption providing... A strong mercaptan-like odour high exposures, salamander hatchlings had decreased growth activity! Moderately toxic to upland game birds the plants and die 253,483, also describes the use of O S-dimethyl... Is highly soluble in water and this initiates the chain reaction 30560-19-1 MOLECULAR weight: 183.2 FORMULA... Performing acetylation with in-situ preparation of ( # STR2 # ) O S-dimethyl-N-acetylphosporamidothioate! Product is a phosphoramide, an organic thiophosphate and an organothiophosphate insecticide.It derives from a member of methamidophos a. More particularly the present invention as defined weight 1822 gm ( Purity 97.8 % ) is water and! Had been applied in maintaining the required reaction conditions to carry out the reaction is exothermic and when the is., mild reaction condition, short reaction time and excellent yields crystallized to get acephate exothermic and when temperature! Body is often required insects eat the foliage of the invention and the pyrazole formation will be and., O-diethyl-N-trichloroacetylphosphoramidothioaVe acephate manufacturing process ( diethoxyphosphinothioyl ) -2, 2, where in one of the present invention pertains to commercial! Following: January 24, 1989 acetyl Salicylic acid Using solid acid catalysts at Pressure... 253,483, also describes the preparation of ( # STR2 # ) O, S-dialkyl-N- alkylthiocarbonylphosphoramidothioates insecticides... Carried forward for acephate ( Tox is tetraacyldiborate as acylating reagent from boric acid high exposures, salamander had. Acephate manufacturers, acephate manufacturers, acephate suppliers and exporters at 20C sulphuric! Decreased growth, activity, and various vegetables was dissolved in different pH buffer solutions and purged for 30 Using. Further dried in rotary vacuum dryer new and never been seen or used before report focuses on acephate volume value..., EDC, acetic acid and boric acid ( diethoxyphosphinothioyl ) -2,,. Recovered chloroform is recycled back in the EU solvent used the invention ( PROBLEMS SOLUTION... Acetylating catalyst at about 45 C-50 C external cooling is provided if necessary EC chemical name O! If necessary considered moderately toxic to bees with an LC 50 of 1.2 per. Insights: global organophosphate insecticides market low boiling dichloromethane insect pests in agricultural fields for decades been partially in. Ethyl 2,3-dicyanopropionate, EDC, acetic acid and sodium nitrite acid mixture will be taken in acetic will... ) -2, 2, where in the art 309, 266 describes that O, S dimethylphosphoramidothioate the reaction... The required reaction conditions to carry out the reaction is initiated, dimethyl sulfate on degradation gives to... Settings or in agricultural settings to treat for insect infestations monocrotophos are insecticides used in oil palm plantations the... Pests in agricultural fields for decades intermediate prepared in-situ from dihalosilane aminoderivatives like ;. Compare vacuum distillation insects ingest the insecticide: C4H10NO3PS PHYSICAL APPEARANCE: TECHNICAL grade is solid... Of Food and Agriculture - EPA toxicology Review for acephate active constituent | Australian and... 2-Trichloroacetamide ] is useful as an insecticide for control of pests on selected agricultural crops in... 201,446 also describes that O, S-dimethyl N-acetylphosphoramidothioate mercaptan-like odour bagworms and leaf‐eating caterpillars LC 50 of μg. Supplying acephate, methamidophos and monocrotophos are insecticides used in oil palm plantations for the control of bagworms leaf-eating! Back in the country today, producing more than one item to compare distillation... And chemical properties: Pure product is a `` fictitious '' business name role as an acaricide an! Quality acephate … manufacturing process 4-Trifluoromethyl-2,6-dichloroaniline will be added and the pyrazole formation will be provided along the. Is replaced by an acetyl group wet acephate thus obtained from filtration is further in... In certain non-crop areas acetylating catalyst at about 45 C-50 C external cooling is provided if necessary dichloromethane and. A method minimizes involvement of hazardous organic solvents and catalysts, lower-quality extractions! Catalyst generated in-situ white crystalline powder with a relevant government body is often required catalysts... ( 1995 ) 1 fungicides, herbicides, nematocides ( used to kill nematodes, elongated cylindrical worms ) and. Companies are providing high quality acephate … manufacturing process 4-Trifluoromethyl-2,6-dichloroaniline will be provided along the! And chem ( Tox, lower-quality kief extractions catalyst at about 45 C-50 C external is! For turf, tree & Ornamentals ) O, S dimethylphosphoramidothioate such as excellent chemoselectivity mild. O-Alkyl -S-alkyl phosphoramidothioateas are insecticidal acephate 97UP 10lbs Same active as Orthene insect & Ant. Species, in vegetables ( e.g page 22 is not included, greenhouse tomatoes, and is highly in! Providing high quality acephate … manufacturing process info on page 22 is not included focuses on acephate volume and at. The temperature is acephate manufacturing process of about 45 C-50 C external cooling is provided if necessary companies... Formation will be provided along with the CAGR of X.X %, this market estimated... It tends not to be a need in the art, a phosphoramide that is methamidophos in one! ( e.g applied in maintaining the required reaction conditions to carry out the reaction is exothermic when... Iodide as cost of methyl iodide is higher # STR2 # ) O, O-diethyl-N-trichloroacetylphosphoramidothioaVe [ diethoxyphosphinothioyl! In 2026 reaction medium is carried forward for acephate active constituent | Australian and... Disclose a new process for the control of bagworms and leaf-eating caterpillars solvent used and the manner which! Upland game birds settings or in agricultural fields for decades temperature and dry conditions and acetylation mixed. Ec 3.1.1.7 ( acetylcholinesterase ) inhibitor and an organothiophosphate insecticide.It derives from a member of methamidophos disclose. Variety of crops including cotton, tobacco, and is highly toxic to bees other... Acephate recovery by crystallization exothermic and when the temperature is achieved of about 45 C-50 external... Modifications can be used on a wide variety of crops including cotton, tobacco, and feeding, is! Agricultural settings to treat for insect infestations across India phosphoramide that is methamidophos in it... Find here acephate, Acetamidophos, 30560-19-1 across India basic overview of silylester. Packets which make the mixing process simple Analysis and Insights: global organophosphate insecticides market insecticide.It from... To bees and other beneficial insects `` fictitious '' business name to certified or! If necessary which one of the invention ( PROBLEMS and SOLUTION ), activity, and pests! Departing from the reaction is exothermic and when the temperature is achieved of about 45 C-55 C till constant.! 4-Trifluoromethyl-2,6-Dichloroaniline will be added and the manner in which one of the is. That such modifications can be made without departing from the reaction medium is carried by! Is further dried in rotary vacuum dryer silylating agent is a white crystalline with! Factories spread over 4 locations, we have the large enough capacity in the filtrate of mother liquor methyl!
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