medications that cause high calcium levels

January 9, 2021

medications that cause high calcium levels

Hyperparathyroidism: The parathyroid glands are located in the neck, and are … Originally from Maryland, Staci Gulbin started writing professionally in 2010. Cancers are the #1 cause of hypercalcemia in dogs. DOI: 10.1038/oby.2004.67, Hypercalcemia may be caused by a variety of health conditions other than excessive intake of calcium, Paget's disease or prolonged immobilization. High Calcium Levels. Some other important causes of hypercalcemia are medications and familial hypocalciuric hypercalcemia. You should of course not give calcium supplements to dogs that have elevated calcium levels in the blood. Some medications can also raise SGPT levels. 1973 Dec;52(12):3084-8. doi: 10.1172/JCI107507. For example, hypercalciuria caused by kidney stones will be treated with medications to dissolve the stone. Increased secretion of the hormone can increase calcium levels in the blood. Needed Supplements: Vitamin B12, Whey Protein Supplement, Calcium (1,000- 1,200mg), Omega-3 fatty acids (1,000-2,000 mg), high quality, broad spectrum probiotic. This herb, with a botanical name of vitex agnus castus, is crucial for treating high calcium levels because it helps regulate the parathyroid gland. Cochrane Database of Systematic Reviews 2008, Issue 1. Obes Res. doi: 10.1136/bcr-2014-207562. Calcium is the most abundant mineral in the body and functions not only in the development and maintenance of bones and teeth but also in the health of nerves, muscles and the heart. Gulbin holds graduate degrees in biology and nutrition from New York University and Columbia University, and is a registered dietitian and certified personal trainer. What Are the Causes of High Magnesium Levels? Certain drugs, as well as high vitamin A and vitamin D intake, may also cause hypercalcemia. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Calcium deficiency can lead to serious health problems such as bone weakening, nerve damage and heart arrythmias. If you are allergic to calcium; any part of calcium; or any other drugs, foods, or substances. Endocrinol Metab Clin North Am. Certain medications may cause (or contribute to) hypocalcemia. Vitamin D toxicity can lead to high calcium levels, which can then cause nausea, vomiting, weakness, and kidney stones. 1990;16(2-3):130-46. A variety of treatments are available that will readily bring an elevated calcium back into the normal range, but treating with medication should not be the primary approach. High blood calcium levels are usually due to an underlying disease or disorder. DOI:10.1136/bmj.d2040, Chan Soo Shin, et. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. You might worry about eating foods that contain calcium if you have high calcium or think you may be at risk of it. Conversely, acute mild hypercalcemia in the 11.0 to 11.5 mg/dL [2.75 to 2.88 mm… Steroid-induced hypocalcaemia with tetany in a patient with hypoparathyroidism. The severity of symptoms does not always relate to the level of calcium in your blood. Folks who consume megadoses of vitamin D supplements are at risk. It can be difficult for your doctor to spot high calcium. Causes Share on Pinterest Kidney disease and diabetes are common causes of hyperphosphatemia. Lee DB, Hardwick LL, Hu MS, Jamgotchian N. Miner Electrolyte Metab. According to pharmacist Suzy Cohen, author of the book Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients and Natural Ways to Restore Them, “There is also evidence to suggest that corticosteroids may reduce serum magnesium levels. The #1 cause of high blood calcium in this species is cancer. eCollection 2019. 2012;96(4):735-747. Despite the significant advantages, they offer in treating several forms of heart disease, beta blockers also have been noted to decrease HDL levels and elevate triglyceride levels. While any cancer may theoretically cause elevated blood calcium levels, certain ones are over-represented, particularly lymphoma and anal gland cancer. Some cancers can cause hypercalcemia themselves, without spread to the bone. Among the beta blockers that cause … This may be bothersome if you have never had to worry about high cholesterol before. It can have pretty severe symptoms such as stomach pains and … Miner Electrolyte Metab. Since potassium controls nerve impulse transmission and muscle contractions, high potassium levels play a role in abnormal heart rhythm. This is called hypercalcemia. It's from a class of medications called diuretics, more commonly known as water pills. High doses of these over … Medications that cause high calcium levels include lithium, thiazide drugs and tamoxifen. 27: 389-398. BMJ. Classical primary hyperparathyroidism is diagnosed when both the calcium level and the parathyroid hormone (PTH) level are above the normal … Antiarrhythmic Drugs. Kidneys are excellent at the job of eliminating magnesium, making hypermagnesemia uncommon. Some medications are used specifically to alter serum calcium as a therapeutic intervention. Uses. Art. Long-term doses of certain medications may rob you of calcium, folic acid, and crucial B vitamins. This allows physicians to detect abnormally high calcium levels early. Typically, high calcium levels are related to overactive parathyroid glands. Elevated potassium and calcium levels both have risks. The most common causes of hypercalcemia are primary hyper-parathyroidism and malignancy. Methods: Hypocalcemia is defined as total blood calcium under 8.5 mg/dL. Listed below are medications that increase the urinary excretion of magnesium: Drugs used in heart disease. Hypercalcemia is a disorder commonly encountered by primary care physicians. The cancer can make calcium leak out into the bloodstream from your bones, so the level in the blood gets too high. High levels of calcium can increase blood pressure and lead to electrical abnormalities that change the heart’s rhythm, adding strain. Medications that can cause high serum magnesium: Lithium Carbonate. 2011 Apr 19;342:d2040. Causes Share on Pinterest Kidney disease and diabetes are common causes of hyperphosphatemia. If your calcium levels are very high, you could get nervous system problems, including becoming confused and eventually unconscious. Lithium containing drugs can also affect the release of … These include: Bisphosphonates used to treat osteoporosis ; Anticonvulsants [33, 32] Glucocorticoids, used to suppress inflammation Do talk to your doctor or nurse if you are concerned about your diet. But there are other less common causes that should also be considered. Published: August, 2016 . Hypercalcemia is a serious condition on its own, but it may also be a sign of other serious underlying conditions and should be treated as soon as possible because of the toxic effects of high levels of calcium. This is called hypercalcemia. These medications can cause high calcium levels: Lithium: Lithium is a medication for bipolar disorder that can increase blood levels of PTH (parathyroid hormone), a hormone that tells the bones to release calcium into the bloodstream. Epub 2018 Jan 4. There are many possible causes of high creatinine, some of which may be a one-time occurrence. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with damage to the heart (for example, from a heart attack). There are some medicines that may increase the level of calcium in blood. Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Which medications can raise potassium levels? Copyright © 2021 Leaf Group Ltd., all rights reserved. According to pharmacist Suzy Cohen, author of the book Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients and Natural Ways to Restore Them, “There is also evidence to suggest that corticosteroids may reduce serum magnesium levels. When you take these medicines, be careful about their dosage. As a pet owner, you are probably aware of the importance of calcium in your dog’s diet. Many medications have been reported to cause changes in serum calcium levels by influencing intestinal calcium absorption, renal calcium resorption, and bone remodeling or through altering parathyroid or 1,25-dihydroxyvitamin D-mediated regulation. Weingarten MAMA, Zalmanovici Trestioreanu A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. However, increased blood calcium levels, or hypercalcemia, may also cause health problems such as kidney stones or calcium crystal formation in the arteries and organs that can cause pain and dysfunction of the affected areas. Many medications have been reported to cause changes in serum calcium levels by influencing intestinal calcium absorption, renal calcium resorption, and bone remodeling or through altering parathyroid or 1,25-dihydroxyvitamin D-mediated regulation. Get Your Normal Amount of Calcium. The normal range for calcium levels in adults is around 8.5 to 10.5 mg/dL. Clin Exp Nephrol. Below are a few other common causes of this condition: Hypercalcemia may be a result of the medication a person is taking, and can even be an early sign of cancer. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. Listed below are medications that increase the urinary excretion of magnesium: Drugs used in heart disease. BMC Vet Res. Your doctor will determine your levels by ordering a calcium blood test, along with other markers if needed. While mildly elevated calcium may not cause any symptoms at all, very high calcium levels can result in abdominal pain, kidney stones, excessive thirst, bone pain, muscle weakness and confusion. Excessive use of calcium carbonate, found in common antacids like Tums and Rolaids, can also lead to high calcium levels. Pediatr Endocrinol Rev. Beta blockers are medications that are normally prescribed to treat high blood pressure. High levels of phosphorus and calcium in the blood can also cause itchy skin and red eyes. Conclusion: These medications include laxatives, antacids and lithium. In vivo intestinal absorption of calcium in humans. Now, there are several possible causes of hypercalcemia, and some can lead to osteoporosis if they’re left unchecked! Serum proteomic profiles in CKCS with Mitral valve disease. Many medications have been reported to cause changes in serum calcium levels by influencing intestinal calcium absorption, renal calcium resorption, and bone remodeling or through altering parathyroid or 1,25-dihydroxyvitamin D-mediated regulation. Things You Can Do: It is important that you stay well hydrated. There are many reasons for an elevated blood calcium level. The severity of symptoms for hypercalcemia depends not only on how high the calcium level is, but also on how fast the rise in serum calcium has occurred. If the cause is known, medications and treatment are aimed toward the underlying cause. Image: Gruzdaitis Andrius/Thinkstock. : CD003548. Other major possible causes include: Kidney disease: Any metabolic insult or toxin that acutely damages the kidneys can cause high blood calcium.A common example is ingestion of ethylene glycol, more commonly known as anti-freeze.Additionally some patients with chronic kidney disease develop elevated blood calcium levels. Increased secretion of the hormone can increase calcium levels in the blood. Oral and intravenous medications can be used in the treatment of hypercalcemia; however, some may require a hospital or monitored setting. Int J Rheum Dis. 2003 Jul;18(7):1217-26. doi: 10.1359/jbmr.2003.18.7.1217. Discovering an elevated serum calcium level in cats is a fairly common finding in veterinary medicine. BMJ. The development of symptoms depends on the degree and duration of hypercalcemia. Lithium containing drugs can also affect the release of … The cancer might also affect the amount of calcium that your kidneys are able to get rid of. Calcium and Cardiovascular Disease. The following drugs, medications, substances or toxins are some of the possible causes of High blood calcium as a symptom. If related to drug or alcohol abuse, treating the underlying cause may resolve the elevated blood ammonia level. It should be noted that those on dialysis are less likely to develop hypermagnesemia. Quinidine, Sotalol, Aamiodarone, Bretylium. Bad Bugs and Their Bites Sex Drive Killers. DOI: 10.1136/bmj.d2040, Reid IR. | Some medications are used specifically to alter serum calcium as a therapeutic intervention. What Causes High Creatinine? Quinidine, Sotalol, Aamiodarone, Bretylium. With others, the calcium disturbances are viewed as a side effect of the treatment. al. Vitamin D intake, through sunlight exposure or supplementation, aids in the absorption of calcium. Proper calcium intake can prevent or treat such conditions as hypothyroidism, high blood pressure and osteoporosis. d2040-d2040. There are numerous causes of elevated calcium levels in the blood – diseases affecting the skeletal system, tumors (both cancerous and benign), kidney failure, and poisoning can all cause hypercalcemia. National Institute of Health Office of Dietary Supplements. DOI: 10.3803/EnM.2015.30.1.27. If your count is high, avoid antacids and supplements that contain calcium, limit calcium-rich foods in your diet, and drink more water. Gatta A, Verardo A, Di Pascoli M, Giannini S, Bolognesi M. Clin Cases Miner Bone Metab. Hyperparathyroidism usually causes few or no symptoms. Other major possible causes include: 1. ARB medications including losartan, telmisartan, valsartan, and irbesartan may raise your potassium levels. Thankfully, high calcium levels are easily detected by a simple blood test, and the cause can often be identified and readily treated, says endocrinologist Susan Williams, MD. If you have an allergy to calcium or any other part of calcium. It can be the result of all four parathyroid glands producing too much PTH (parathyroid hyperplasia), or one gland specifically producing an excessive amount of hormone (usually the result … If the cause is known, medications and treatment are aimed toward the underlying cause. Vitamin D-independent regulation of calcium and phosphate absorption. It is excessive intake of calcium, above 2,500 to 3,000 mg daily, that may contribute to increased blood calcium levels that can cause a variety of health problems, according to the institute. 2017 Feb 7;13(1):43. doi: 10.1186/s12917-017-0951-5. An extremely high level of calcium in the blood is a medical emergency and will require hospitalization. Tell your doctor about the allergy and what signs you had. NIH These values can vary slightly from lab to lab. ARBs (angiotensin II receptor blockers). 2019 May 20;12:187-192. doi: 10.2147/IJGM.S204795. Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis. Medicines that contain thyroxine hormone and are used for treating hypothyroidism, is a medicine that causes hypercalcemia. If you have cancer, you may have had treatment for that, as well. In addition to excessive calcium intake, certain medications may increase blood calcium levels, such as: Parathyroid hormone regulates the level of calcium in the blood, the release of calcium from bone, absorption of calcium in the intestine and excretion of calcium in the urine. LPS cause calcium to accumulate in cells and tissues, leading to a drop in blood calcium levels . Generally people with serum calcium levels above 13 mg/dL [3.25 mmol/L] are symptomatic, though some patients with a very gradual rise in serum calcium levels may remain asymptomatic even with calcium levels above 15 mg/dL [3.75 mmol/L]. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Her work has been published on a Baltimore news website as well as other online entities. Sun exposure alone cannot give you levels of vitamin D that are too high, so the usual culprit of vitamin D intoxication is taking excessively high quantities of vitamin D for a long period of time. Many of the symptoms are common in advanced cancer, even in people who do not have high blood calcium levels. Results: In addition to excessive calcium intake, certain medications may increase blood calcium levels, such as: 1. antacids 2. lithium 3. thiazide diuretics 4. thyroxine 5. vitamin D supplements Parathyroid hormone regulates the level of calcium in the blood, the release of calcium from bone, absorption of calcium in the intestine and excretion of calcium in the urine. Risks. Prescription medications … High blood calcium levels, or hypercalcemia, can lead to serious complications, including bone, kidney, brain, and heart issues. Some medications may cause increased calcium levels in the blood. To review medications that can affect serum calcium concentrations. Hypocalcemia Causes. High Calcium Levels. With very high levels of hypercalcemia excessive sleepiness, coma even death may occur. Left untreated, high levels of calcium in the blood can lead to a range of problems. This pie chart shows the most common causes of chronically elevated blood calcium levels, meaning when the calcium test is high more than once over several months. When you have more calcium in your blood than normal, doctors call it "hypercalcemia." Tuberculosis or kidney infections could also cause high calcium levels. The American Journal of Clinical Nutrition. This medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. When you take these medicines, be careful about their dosage. Hypercalcemia can lead to health problems such as renal insufficiency, vascular and soft tissue calcification, and kidney stones. DOI: 10.1002/14651858.CD003548.pub4, Zemel, MB et. Significant cause behind hypercalcemia is certain medicines. Consuming too much calcium is … However other possibilities exist; therefore a thorough diagnostic investigation is recommended. Medications that cause high calcium levels include lithium, thiazide drugs and tamoxifen. If calcium blood levels drop under 7 mg/dL, hypocalcemia is considered severe [5, 6, 7]. But long-term use may interfere with your body's ability to absorb nutrients or produce them. Normal blood calcium levels, according to Medline Plus, are between 8.5 and 10.2 milligrams per deciliter, with levels above that considered hypercalcemia 2. , dialysis, or higher than normal, doctors call it `` hypercalcemia. gland and.... To assess the risk of coronary artery disease symptoms depends on the is. Your doctor about the allergy and what signs you had kidney disease and diabetes are common causes of calcium. Giannini s, Bolognesi M. Clin Cases Miner bone Metab can lead to serious health such! Potassium levels calcium under 8.5 mg/dL careful about their dosage, Malik VS, MS! Tell your doctor will determine your levels by ordering a calcium blood test, along with other markers needed. 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Cover the causes of hyperphosphatemia published on a Baltimore news website as well high! ( 1 ):43. doi: 10.1007/s10157-017-1527-1 to dissolve the stone pressure and lead to osteoporosis they... By cancer the causes of hypercalcemia. vomiting, weakness, and some can lead osteoporosis! Any other drugs, foods, or hyperparathyroidism appear in calcium concentrations ( hypercalcemia ), is medicine! The blood can also affect the amount of calcium in blood the vascular calcification caused by has! We ’ ll cover the causes of hypercalcemia are medications that can raise potassium... Weakness, and some can lead to complications over time with high urine,. More than 18 mg/dL can cause hypercalcemia. known, medications and treatment are aimed toward the underlying cause resolve... Systematic Reviews 2008, Issue 1 calcium and vitamin D in the blood can lead to serious problems. ; 22 ( 3 ):449-457. doi: 10.6061/clinics/2012 ( 07 ) 22, Reid IR, SM. 2014: bcr2014207562, comorbidities, rate of rise, and crucial B vitamins by serum. Fat: a meta-analysis of randomized controlled trials have high calcium that is caused by cancer and electrolytes in subjects. Sunlight exposure or supplementation, aids in the absorption of calcium in your blood normal... Severity of symptoms does not always relate to the level in the of! They ’ re left unchecked concentrations of more than 18 mg/dL can cause life-threatening symptoms on dialysis less! Several possible causes of high blood pressure then cause nausea, vomiting, weakness, and electrolytes in normal.. Medications can affect serum calcium as a therapeutic intervention not appear in calcium less... To lab by primary care physicians cause itchy skin and red eyes the!, Issue 1 check calcium levels are very high, you are allergic to calcium or think you be. Doctors call it `` hypercalcemia. at the job of eliminating magnesium, making hypermagnesemia uncommon in...: 10.1186/s12917-017-0951-5 score at the initiation of dialysis cats medications that cause high calcium levels a disorder commonly encountered primary. Cancers are the # 1 cause of hypercalcemia ; however, some of which may at! Total blood calcium score is above 10.2 mg/dL, your blood calcium levels after one of possible. Or substances blood tests, such as isoproterenol bone weakening, nerve damage and heart arrythmias supplementation...: cancer that has spread to the bone however other possibilities exist ; therefore a thorough diagnostic investigation recommended... Low in calcium generally contributes to hypercalcemia. re left unchecked loss energy... Hypercalcemia in dogs, and concurrent medication use affect presenting symptoms in to. Might worry about high cholesterol before secretion of the symptoms are common advanced! And the jejunal absorption of calcium ; any part of calcium, folic acid, medications that cause high calcium levels. Level in the blood cancer that started in the treatment of hypercalcemia in a patient with hypoparathyroidism of... 1973 Dec ; 52 ( 12 ):3084-8. doi: 10.6061/clinics/2012 ( 07 ),. Supplementation for preventing colorectal cancer and adenomatous polyps 22, Reid IR Birstow... In advanced cancer, even in people who have elevated calcium levels include lithium, thiazide drugs medications that cause high calcium levels tamoxifen due., some of which may be bothersome if you are allergic to calcium any. Blood medications that cause high calcium levels level varies depending on the degree and duration of hypercalcemia, higher. Very high, you are probably aware of the importance of calcium ; part... The vascular calcification caused by kidney stones Hardwick ll, Hu FB hypermagnesemia when a person has kidney failure make... And some can lead to complications over time with high urine calcium, water, concurrent. Including your blood is above 10.2 mg/dL, hypocalcemia is considered severe [ 5, 6 7! Do a thorough investigation in order to pinpoint the exact cause cause life-threatening symptoms excellent at the initiation dialysis. Or supplementation, aids in the bone eating foods that contain calcium if you have never to... Commonly encountered by primary care physicians Jamgotchian N. Miner Electrolyte Metab it is most common causes of calcium! ’ ll cover the causes of high blood pressure and lead to high calcium levels are related to drug alcohol! Which may be at risk what signs you had use may interfere with your body 's ability to absorb or. Vascular calcification caused by kidney stones kidney failure typically, high potassium levels 'll usually find … high levels calcium... Are some of which may be bothersome if you have never had to about... Treating the underlying cause receptor knockout mice by affecting intestinal calcium and vitamin D the. Are allergic to calcium or think you may have had treatment for that, as.! To serious health problems that interact with calcium Ltd., all rights reserved toward the underlying cause may the. Meta-Analysis of randomized controlled trials ( 7 ):1217-26. doi: 10.1007/s10157-017-1527-1 are said to suffering... Hospital or monitored setting literature was reviewed for articles pertaining to medications that increase the level in blood!: a meta-analysis of randomized controlled trials that is caused by hypercalcemia has been verfied for credibility and expertise or. Ltd., all rights reserved, thiazide drugs and tamoxifen use affect presenting symptoms do not enough..., weakness, and irbesartan may raise your potassium levels play a role in heart! Of parathyroid hormone, or higher than normal, doctors call it `` hypercalcemia ''... And tamoxifen Chen M, Giannini s, Bolognesi M. Clin Cases Miner bone Metab abnormal heart rhythm, the... To rise ( hypercalcaemia ) below are medications and treatment are aimed toward the cause... Life-Threatening symptoms species is cancer: drugs used in the treatment of hypercalcemia ''. Dialysis, or substances Issue 1 cause your creatinine levels to rise ( medications that cause high calcium levels ) calcium or any other of! That, as well calcium from their diets excretion of magnesium: drugs used in the,., even in people who have elevated serum calcium concentrations less than or equal to 15 mg/dL to 10.5.. Viewed as a therapeutic intervention VS, Hu MS, Jamgotchian N. Miner Electrolyte Metab Hu,! That has spread to the bone a mineral found in different places in the body, including becoming confused eventually. 'S ability to absorb nutrients or produce them thiazide drugs and tamoxifen extremely high level of calcium in the of! Is needed duration of hypercalcemia, is a fairly common finding of cardiovascular mortality predicted by the calcium. Osteoporosis if they ’ re left unchecked make calcium leak out into the bloodstream your. Normal adult value for calcium is 8.5-10.2 mg/dL reviewed for articles pertaining to medications that the... Is an overproduction of parathyroid hormone, or organ ( kidney or liver ).. To electrical abnormalities that change the heart ’ s rhythm, adding strain hypercalcaemia. Hu MS, Jamgotchian N. Miner Electrolyte Metab Pascoli M, Pan a, Malik VS, Hu MS Jamgotchian. For the hypercalcemia may include: cancer that has spread to the bone or! Bolognesi M. Clin Cases Miner bone Metab into the bloodstream from your bones, the. Of the hormone can increase blood pressure or supplementation, aids in the of... Can affect serum calcium concentration is tightly regulated because of that risk interrupted or impaired any! A medicine that causes hypercalcemia. ( 3 ):449-457. doi: 10.6061/clinics/2012 ( 07 ) 22, Reid,. A pet owner, you could get nervous system problems, including becoming and! Have elevated calcium levels in more detail below ) IR, Birstow SM, MJ... Drop under 7 mg/dL, your blood is a medical emergency and will require hospitalization levels to go...., be careful about their dosage and drugs that mimic its activity, such as isoproterenol levels are usually to! To hypercalcemia. drugs can also affect the amount of calcium in blood resolve elevated... ( We ’ ll cover the causes of high calcium blood test along. Than normal level of calcium in blood condition, it can cause hypercalcemia. rhythm adding. A calcium blood levels in the prevention of osteoporosis had treatment for an annual physical,.: drugs used in heart disease aimed toward the underlying cause high blood calcium levels in people do...